来自阿比西尼亚刺桐根皮的具有抗疟活性的黄酮类化合物和异黄酮类化合物。

Flavonoids and isoflavonoids with antiplasmodial activities from the root bark of Erythrina abyssinica.

作者信息

Yenesew Abiy, Derese Solomon, Irungu Beatrice, Midiwo Jacob O, Waters Norman C, Liyala Pamela, Akala Hoseah, Heydenreich Matthias, Peter Martin G

机构信息

Department of Chemistry, University of Nairobi, Nairobi, Kenya.

出版信息

Planta Med. 2003 Jul;69(7):658-61. doi: 10.1055/s-2003-41119.

DOI:10.1055/s-2003-41119

PMID:12898424

Abstract

From the root bark of Erythrina abyssinica a new pterocarpene [3-hydroxy-9-methoxy-10-(3,3-dimethylallyl)pterocarpene] and a new isoflav-3-ene [7,4'-dihydroxy-2',5'-dimethoxyisoflav-3-ene] were isolated. In addition, the known compounds erycristagallin, licoagrochalcone A, octacosyl ferulate and triacontyl 4-hydroxycinnamate were identified. The structures were determined on the basis of spectroscopic evidence. The crude extract and the flavonoids and isoflavonoids obtained from the roots of this plant showed antiplasmodial activities.

摘要

从阿比西尼亚刺桐的根皮中分离出一种新的紫檀烯[3-羟基-9-甲氧基-10-(3,3-二甲基烯丙基)紫檀烯]和一种新的异黄酮-3-烯[7,4'-二羟基-2',5'-二甲氧基异黄酮-3-烯]。此外，还鉴定出了已知化合物刺桐晶、甘草查耳酮A、二十八烷基阿魏酸酯和三十烷基4-羟基肉桂酸酯。结构是根据光谱证据确定的。该植物根的粗提取物以及从中获得的黄酮类化合物和异黄酮类化合物表现出抗疟活性。