阴道棘豆根中的酚类成分。

Phenolic constituents of Ononis vaginalis roots.

作者信息

Abdel-Kader M S

出版信息

Planta Med. 2001 Jun;67(4):388-90. doi: 10.1055/s-2001-14325.

DOI:10.1055/s-2001-14325

Abstract

The ether soluble fraction of the roots of Ononis vaginalis Vahl. Symb. afforded three new compounds: 3-hydroxy-4,9-dimethoxycoumestan, maginaldehyde [2-(4-hydroxy-2-methoxyphenyl)-5,6-dimethoxy-3-benzofuran-carboxaldehyde] and 5,7,4'-trihydroxy-4-styrylcoumarin. In addition, four known pterocarpans; 3,4,9-trimethoxypterocarpan, maackiain, medicarpin and trifolirhizin were also isolated. The styrylcoumarin derivative showed significant antiviral activity against Herpes simplex type 1 and weak cytotoxicity.

摘要

阴道芒柄花（Ononis vaginalis Vahl. Symb.）根的乙醚可溶部分提供了三种新化合物：3-羟基-4,9-二甲氧基香豆雌酚、芒柄醛[2-(4-羟基-2-甲氧基苯基)-5,6-二甲氧基-3-苯并呋喃甲醛]和5,7,4'-三羟基-4-苯乙烯基香豆素。此外，还分离出四种已知的紫檀烷类化合物；3,4,9-三甲氧基紫檀烷、刺芒柄花素、美迪紫檀素和三叶豆紫檀苷。该苯乙烯基香豆素衍生物对单纯疱疹病毒1型显示出显著的抗病毒活性，且细胞毒性较弱。