Noviany Noviany, Samadi Arash, Yuliyan Nita, Hadi Sutopo, Aziz Muhammad, Purwitasari Neny, Mohamad Suriyati, Ismail Nur Najihah, Gable Kevin P, Mahmud Taifo
Department of Chemistry, Faculty of Mathematics and Natural Sciences, University of Lampung, Bandar Lampung 35145, Lampung, Indonesia.
Department of Pharmaceutical Sciences, Oregon State University, Corvallis, Oregon 97331-3507, USA.
Phytochem Lett. 2020 Feb;35:211-215. doi: 10.1016/j.phytol.2019.12.008. Epub 2019 Dec 30.
A new 2-arylbenzofuran, sesbagrandiflorain C (), together with four known compounds, 2-(3,4-dihydroxy-2-methoxyphenyl)-4-hydroxy-6-methoxybenzofuran-3-carbaldehyde (, 2-(4-hydroxy-2-methoxyphenyl)-5,6-dimethoxybenzofuran-3-carboxaldehyde (), sesbagrandiflorain A () and sesbagrandiflorain B (), have been isolated from the stem bark of an Indonesian plant, (L.) Pers. The chemical structure of compound was elucidated by UV, IR, MS, and NMR spectroscopic techniques. The proton and carbon NMR resonances of were also compared with the predicted chemical shifts obtained from DFT quantum mechanical calculations with Gaussian. None of the compounds showed antibacterial activity against , , , and in an agar diffusion assay. However, sesbagrandiflorains A () and B () exhibited moderate activity against H37Rv. In addition, compounds - have moderate cytotoxicity against HeLa, HepG2, and MCF-7 cancer cell lines.
一种新的2-芳基苯并呋喃，倍半大花素C（），与四种已知化合物，2-(3,4-二羟基-2-甲氧基苯基)-4-羟基-6-甲氧基苯并呋喃-3-甲醛（）、2-(4-羟基-2-甲氧基苯基)-5,6-二甲氧基苯并呋喃-3-甲醛（）、倍半大花素A（）和倍半大花素B（），已从一种印度尼西亚植物（L.）Pers.的茎皮中分离出来。化合物的化学结构通过紫外、红外、质谱和核磁共振光谱技术得以阐明。还将的质子和碳核磁共振共振与通过高斯密度泛函理论量子力学计算得到的预测化学位移进行了比较。在琼脂扩散试验中，这些化合物均未显示出对、、、的抗菌活性。然而，倍半大花素A（）和B（）对H37Rv表现出中等活性。此外，化合物 - 对HeLa、HepG2和MCF-7癌细胞系具有中等细胞毒性。
