Fang Y R, Huang Y S, Wu J C, Chao Y, Tsay S H, Chan C Y, Chang F Y, Lee S D
Division of Gastroenterology, Department of Medicine, Taipei Veterans General Hospital, 201, Sec. 2, Shih-Pai Road, Taipei 112, Taiwan.
Zhonghua Yi Xue Za Zhi (Taipei). 2001 Apr;64(4):253-7.
Cutaneous metastases from hepatocellular carcinoma are rare. In this report we detail a case of hepatocellular carcinoma with the unusual manifestations of multiple skin metastases. A 49-year-old male, who had received surgical resection of hepatocellular carcinoma one year prior, presented with multiple reddish-blue, firm, painless and nonulcerative cutaneous papules and nodules over the fingers, palms, toes, soles and back. Pathology of the cutaneous nodules showed characteristic hepatocellular carcinoma with trabecular gland formation. These lesions grew very rapidly and developed to cauliflower appearances which had not been described previously in the literature. The patient died of respiratory failure secondary to lung metastasis two months after the first appearance of the skin lesions.
肝细胞癌的皮肤转移罕见。在本报告中,我们详细介绍了一例具有多发性皮肤转移不寻常表现的肝细胞癌病例。一名49岁男性,一年前接受了肝细胞癌手术切除,现手指、手掌、脚趾、脚底和背部出现多个红蓝色、质地坚硬、无痛且无溃疡的皮肤丘疹和结节。皮肤结节的病理显示为具有小梁状腺体形成的典型肝细胞癌。这些病变生长非常迅速,发展为文献中先前未描述过的菜花状外观。皮肤病变首次出现两个月后,患者死于肺转移继发的呼吸衰竭。