Ohtsuka H, Kudo K, Mori K, Nagai F, Hatsugaya A, Tajima M, Tamura K, Hoshi F, Koiwa M, Kawamura S
Department of Veterinary Internal Medicine, School of Veterinary Medicine and Animal Sciences, Kitasato University, Towada, Aomori, Japan.
J Vet Med Sci. 2001 Jun;63(6):675-8. doi: 10.1292/jvms.63.675.
Changes in the activities of serum cytokines and in acute phase response were observed in dairy cows with naturally occurring coliform mastitis. Seven cows with severe mastitis showed systemic and mammary inflammatory response throughout the observation period, and 11 cows with mild mastitis recovered and were able to be milked within 3 days of onset of mastitis. Serum interleukin (IL)-I and tumor necrosis factor (TNF) activities were higher in the severe group than in the mild group at the first appearance of symptoms. Elevated IL-1 activity was evident in the severe group throughout the observation period. Serum alpha-1-acidglycoprotein (alpha1AG) concentration began to rise with the beginning of mastitis in the severe group, and peaked at 9 days. Serum haptoglobin (Hp) concentrations peaked at 3 days, and decreased gradually after 3 days in the severe group. These results showed that there are dynamic changes in serum IL-1 activity and in serum alpha1AG and Hp concentrations in cows with severe coliform mastitis.
在患有自然发生的大肠杆菌性乳腺炎的奶牛中观察血清细胞因子活性和急性期反应的变化。7头患有严重乳腺炎的奶牛在整个观察期内表现出全身和乳腺炎症反应，11头患有轻度乳腺炎的奶牛康复并在乳腺炎发病后3天内能够挤奶。在症状首次出现时，严重组的血清白细胞介素（IL）-1和肿瘤坏死因子（TNF）活性高于轻度组。在整个观察期内，严重组的IL-1活性明显升高。严重组血清α-1-酸性糖蛋白（α1AG）浓度在乳腺炎开始时开始升高，并在9天时达到峰值。严重组血清触珠蛋白（Hp）浓度在3天时达到峰值，并在3天后逐渐下降。这些结果表明，患有严重大肠杆菌性乳腺炎的奶牛血清IL-1活性以及血清α1AG和Hp浓度存在动态变化。
