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雄性大鼠附属生殖器官的超微结构。7. 一种抗雄激素化合物SK和F 22340的作用。

The ultrastructure of the accessory sex organs of the male rat. 7. The effect of an anti-androgenic compound, SK and F 22340.

作者信息

Tveter K J, Dahl E

出版信息

Urol Res. 1975;2(4):159-66. doi: 10.1007/BF00257265.

DOI:10.1007/BF00257265
PMID:1145909
Abstract

The influence of a potent anti-androgenic compound, SK and F 22340, on the ultrastructure of the lateral and ventral prostate and the seminal vesicles of the rat has been studied. After treatment for 18 days there was macroscopic atrophy of the organs with decreased amount of secretory material. There was reduction of the height and width of the epithelial cells and loss of cytoplasm. The most distinct changes were found in the cytoplasm and comprised a quantitative reduction of the rough endoplasmic reticulum (RER) and of free ribosomes; the Golgi apparatus was reduced and the number of secretion granules were diminished. All the alterations observed are apparently similar to the changes caused by bilateral orchidectomy.

摘要

已对一种强效抗雄激素化合物SK和F 22340对大鼠侧叶和腹侧前列腺以及精囊超微结构的影响进行了研究。治疗18天后，这些器官出现肉眼可见的萎缩，分泌物质减少。上皮细胞的高度和宽度减小，细胞质丧失。在细胞质中发现了最明显的变化，包括粗面内质网（RER）和游离核糖体数量的定量减少；高尔基体减少，分泌颗粒数量减少。观察到的所有改变显然与双侧睾丸切除所引起的变化相似。

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引用本文的文献

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The ultrastructure of the accessory sex organs of the male rat. XII. Nuclear alterations of prostatic epithelial cells induced by anti-androgens.
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本文引用的文献

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QUANTITATIVE STUDIES OF PROSTATIC SECRETION : II. THE EFFECT OF CASTRATION AND OF ESTROGEN INJECTION ON THE NORMAL AND ON THE HYPERPLASTIC PROSTATE GLANDS OF DOGS.前列腺分泌的定量研究：二、去势和雌激素注射对正常和增生犬前列腺的影响。
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The fine structure of the lateral lobe of the rat prostate gland. Comparison with the dorsal and other lobes.大鼠前列腺外侧叶的精细结构。与背叶及其他叶的比较。
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The relative importance of androgen and estrogen in the selective uptake of Zn65 by the dorsolateral prostate of the rat.雄激素和雌激素在大鼠背外侧前列腺对锌65的选择性摄取中的相对重要性。
Endocrinology. 1956 Apr;58(4):443-52. doi: 10.1210/endo-58-4-443.
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Treatment and survival of patients with cancer of the prostate. The Veterans Administration Co-operative Urological Research Group.
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Antagonistic action of anti-androgens on the formation of a specific dihydrotestosterone-receptor protein complex in rat ventral prostate.
Mol Pharmacol. 1969 Jul;5(4):428-31.
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Androgen accumulation andbinding to macromolecules in seminal vesicles: inhibition cyproterone.雄激素在精囊中的积累及与大分子的结合：环丙孕酮的抑制作用
Science. 1969 Oct 10;166(3902):233-5. doi: 10.1126/science.166.3902.233.
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Selective uptake of androgen by rat seminal vesicle.
Endocrinology. 1969 Apr;84(4):963-6. doi: 10.1210/endo-84-4-963.
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Selective uptake of radioactivity in rat ventral prostate following administration of testosterone-1,2-3H. Methodological considerations.
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J Biol Chem. 1968 Nov 25;243(22):5953-60.