雄激素在精囊中的积累及与大分子的结合：环丙孕酮的抑制作用
Androgen accumulation andbinding to macromolecules in seminal vesicles: inhibition cyproterone.
作者信息
Stern J M, Eisenfeld A J
出版信息
Science. 1969 Oct 10;166(3902):233-5. doi: 10.1126/science.166.3902.233.
PMID:5809593
Abstract
Cyproterone reduces the accumulation of testosterone and dihydrotestosterone in seminal vesicles 30 minutes after intravenous administration of tritiated testosterone to castrated rats. Testosterone, added in vitro, binds to macromolecules from the supernatant fraction of the seminal vesicle homogenates; this interaction is antagonized competitively by cyproterone. Cyproterone may diminish androgenic effects by competition for binding molecules.
摘要
给去势大鼠静脉注射氚标记的睾酮30分钟后，环丙孕酮可减少精囊中睾酮和双氢睾酮的蓄积。体外添加的睾酮可与精囊匀浆上清液中的大分子结合；环丙孕酮可竞争性拮抗这种相互作用。环丙孕酮可能通过竞争结合分子来减弱雄激素作用。
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