Liepert J, Bär K J, Meske U, Weiller C
Department of Neurology, Friedrich Schiller University, Jena, Germany.
Clin Neurophysiol. 2001 Aug;112(8):1436-41. doi: 10.1016/s1388-2457(01)00554-5.
To explore subclinical disturbances in the motor cortex of patients with Alzheimer's disease (AD).
We used transcranial magnetic stimulation in a paired pulse technique to test intracortical inhibition (ICI) and intracortical facilitation in mildly to moderately demented AD patients with a normal neurological examination. Patients were studied before and during treatment with the cholinesterase inhibitor donepezil.
AD patients had a reduced ICI compared to an age-matched control group. The amount of disinhibition correlated with the severity of dementia. Treatment with 10 mg donepezil daily was associated with an increase of ICI.
The subclinical motor cortex disinhibition in AD patients indicates a functional disturbance, and is probably associated with a cholinergic deficit.
探讨阿尔茨海默病（AD）患者运动皮层的亚临床功能紊乱。
我们采用经颅磁刺激的配对脉冲技术，对神经系统检查正常的轻度至中度痴呆AD患者进行皮质内抑制（ICI）和皮质内易化测试。在使用胆碱酯酶抑制剂多奈哌齐治疗前和治疗期间对患者进行研究。
与年龄匹配的对照组相比，AD患者的ICI降低。去抑制的程度与痴呆的严重程度相关。每日服用10mg多奈哌齐治疗与ICI增加有关。
AD患者亚临床运动皮层去抑制表明存在功能紊乱，可能与胆碱能缺陷有关。
