Halhal M, D'hermies F, Morel X, Renard G
Service d'ophtalmologie (Pr G. Renard), Hôtel Dieu de Paris, 75181 Paris Cedex 04, France.
J Fr Ophtalmol. 2001 Jun;24(6):628-34.
The ICE syndrome includes 3 variants of the same disease, previously believed to be independent entities. All 3 share clinical and histopathological features such as endothelial abnormalities, iris damage, and progressive closure of the iridocorneal angle. Seven cases of ICE syndrome are reported, affecting 6 women and 1 man, with a mean age of 40 years. Corectopia was found in 5 eyes, a uveal ectropion in 2 cases, and other iris changes in 3 cases. The endothelial changes of the cornea were confirmed by a speculum microscopy in 5 cases. There were 5 cases of Chandler syndrome, 1 of Cogan-Reese syndrome, and 1 case of iris essential atrophy in our series. Ocular hypertony was observed in 3 cases, 2 of which needed to be operated. In one patient, a corneal edema was observed.
ICE综合征包括同一种疾病的3种变体,以前认为是独立的病症。所有3种变体都具有临床和组织病理学特征,如内皮异常、虹膜损害和虹膜角膜角的进行性闭合。报告了7例ICE综合征病例,其中6例为女性,1例为男性,平均年龄40岁。5只眼发现瞳孔异位,2例发现葡萄膜外翻,3例有其他虹膜改变。5例通过房角镜检查证实有角膜内皮改变。本系列中有5例钱德勒综合征、1例科根-里斯综合征和1例虹膜原发性萎缩。3例观察到眼压升高,其中2例需要手术治疗。1例患者观察到角膜水肿。