长期γ-疱疹病毒感染期间病毒特异性CD4(+) T细胞的分析
Analysis of virus-specific CD4(+) t cells during long-term gammaherpesvirus infection.
作者信息
Flaño E, Woodland D L, Blackman M A, Doherty P C
机构信息
Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
出版信息
J Virol. 2001 Aug;75(16):7744-8. doi: 10.1128/JVI.75.16.7744-7748.2001.
Abstract
Major histocompatibility complex class II-mediated antigen presentation after intranasal infection with murine gammaherpesvirus 68 differs in mediastinal lymph nodes and spleen. Evidence that virus-specific CD4(+) T cells were being stimulated was found as late as 6 to 8 months after infection, and cells specific for the viral gp150(67-83) and ORF11(168-180) peptides were maintained as a fairly stable proportion of the total response.
摘要
小鼠γ-疱疹病毒68经鼻内感染后，主要组织相容性复合体II类介导的抗原呈递在纵隔淋巴结和脾脏中有所不同。在感染后迟至6至8个月时发现有证据表明病毒特异性CD4(+) T细胞受到刺激，并且针对病毒gp150(67 - 83)和ORF11(168 - 180)肽的细胞在总反应中保持相当稳定的比例。
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