Roberts D M, Oldrey T B
Am J Gastroenterol. 1975 May;63(5):396-9.
Intravenous diazepam will not significantly suppress gastric secretion within the first hour after "maximal" stimulation with pentagastrin. In the second and third hours, however, gastric secretion is significantly diminished. Further suppression after pentagastrin and diazepam is possible in each of the three post-stimulation hours by the simultaneous administration of atropine. Diazepam does not suppress the seven-hour basal nocturnal gastric secretion during sleep. This suggests that diazepam acts during wakefulness by inhibition of secretory stimuli arising centrally, thus providing a rationale for use of this drug in patients with peptic ulcer in whom stress may be a factor in the pathogenesis.
静脉注射地西泮在五肽胃泌素“最大”刺激后的第一小时内不会显著抑制胃酸分泌。然而，在第二和第三小时，胃酸分泌会显著减少。在刺激后的三个小时内，同时给予阿托品可进一步抑制五肽胃泌素和地西泮刺激后的胃酸分泌。地西泮不会抑制睡眠期间长达七小时的基础夜间胃酸分泌。这表明地西泮在清醒状态下起作用，通过抑制中枢产生的分泌刺激，从而为在应激可能是发病机制因素之一的消化性溃疡患者中使用该药物提供了理论依据。
