Bergegårdh S, Broman G, Knutson U, Palmer L, Olbe L
Scand J Gastroenterol. 1976;11(4):337-46.
Gastric acid responses to graded i.v. infusion of pentagastrin and Histalog were determined in peptic ulcer patients. Single-day multiple-dose tests were performed. The sensitivity to the humoral stimuli as determined by the calculated ED50's was not significantly different for duodenal ulcer patients with moderate (DUmod) or massive (DUmass) observed hypersecretion or for gastric ulcer (GU) patients: median ED50's of pentagastrin were 6.2, 6.6, and 13.1 mug/h in 18 DUmod, 22 DUmass and 7 GU patients respectively, and median ED50's of Histalog were 16.6, 25.3, and 17.1 mg/h in 14 DUmod, 10 DUmass and 6 GU patients respectively. Antrum-bulb resection significantly reduced basal acid secretion and maximal acid responses to the humoral stimuli (about 45% reduction) but did not significantly change the loss of gastric contents to the intestine or the sensitivity to the humoral stimuli (median ED50 of pentagastrin increased from 5.2 to 6.7 mug/h in 14 patients, and median ED50 of Histalog increased from 16.0 to 20.8 mg/h in 12 patients), suggesting that the intact antrum-bulb region of the ulcer patient is controlling the capacity to secrete acid, and indicating that antrum-bulb gastrin is an important trophic factor for the parietal cells in man.
在消化性溃疡患者中测定了静脉内分级输注五肽胃泌素和组胺甲碘化物后的胃酸反应。进行了单日多剂量试验。十二指肠溃疡患者中，中度（DUmod）或大量（DUmass）观察到胃酸分泌过多者，以及胃溃疡（GU）患者，通过计算的半数有效剂量（ED50）确定的对体液刺激的敏感性无显著差异：18例DUmod、22例DUmass和7例GU患者中，五肽胃泌素的中位ED50分别为6.2、6.6和13.1μg/h，14例DUmod、10例DUmass和6例GU患者中，组胺甲碘化物的中位ED50分别为16.6、25.3和17.1mg/h。胃窦-十二指肠球部切除术显著降低了基础胃酸分泌和对体液刺激的最大胃酸反应（约降低45%），但未显著改变胃内容物向肠道的流失或对体液刺激的敏感性（14例患者中五肽胃泌素的中位ED50从5.2增加到6.7μg/h，12例患者中组胺甲碘化物的中位ED50从16.0增加到20.8mg/h），这表明溃疡患者完整的胃窦-十二指肠球部区域控制着胃酸分泌能力，并表明胃窦-十二指肠球部胃泌素是人类壁细胞的重要营养因子。
