在对照双盲交叉条件下静脉注射地西泮对人下食管括约肌压力的影响。
Effect of intravenous diazepam on human lower oesophageal sphincter pressure under controlled double blind crossover conditions.
作者信息
Weihrauch T R, Förster C F, Köhler H, Ewe K, Krieglstein J
出版信息
Gut. 1979 Jan;20(1):64-7. doi: 10.1136/gut.20.1.64.
The effect of diazepam on the lower oesophageal sphincter (LOS) pressure is controversial. Therefore, a double-blind crossover study was performed on 18 healthy volunteers to determine the sphincter response to intravenous diazepam--70, 140, 280 microgram/kg, which correspond to a total dose of 5, 10, and 20 mg. respectively. After the 5 and 10 mg dose no signficant effect on LOS pressure could be observed when compared with placebo. After the 20 mg dose a significant rise in pressures (deltaPLOS) was recorded for 40 minutes with a maximum deltaPLOS of + 16.2 +/- 6.6 (mean +/- SEM) mmHg after 50 minutes (P less than 0.01) (46 +/- 1.3% increase above the basal pressure). It is concluded that diazepam does not affect lower oesophageal sphincter competence and therefore does not increase the risk of regurgitation and pulmonary aspiration in premedicated patients.
地西泮对下食管括约肌（LOS）压力的影响存在争议。因此，对18名健康志愿者进行了一项双盲交叉研究，以确定括约肌对静脉注射地西泮（剂量分别为70、140、280微克/千克，分别相当于总剂量5、10和20毫克）的反应。与安慰剂相比，5毫克和10毫克剂量对LOS压力未观察到显著影响。20毫克剂量后，压力出现显著升高（ΔPLOS），持续40分钟，50分钟时最大ΔPLOS为+16.2±6.6（平均值±标准误）毫米汞柱（P<0.01）（比基础压力升高46±1.3%）。结论是，地西泮不影响下食管括约肌功能，因此不会增加麻醉前用药患者反流和肺误吸的风险。
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