Takubo K, Lambie N K
Department of Clinical Pathology, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan.
J Clin Gastroenterol. 2001 Aug;33(2):141-4. doi: 10.1097/00004836-200108000-00010.
We report a case of Barrett's adenocarcinoma of the esophagus with lymphoid stroma. We believe this is the first reported case of this entity, although six previous cases of esophageal lymphoepithelioma-like carcinoma have been reported. The esophageal tumor from a 58-year-old man was examined histologically. In situ hybridization to detect Epstein-Barr virus (EBV) was also performed. The tumor consisted of a poorly differentiated adenocarcinoma with dense lymphoid cell infiltration in the invasive portions and a well-differentiated adenocarcinoma without lymphoid stroma in the mucosa. Barrett's epithelium was observed adjacent to the carcinoma. No positive signals for EBV were detected in the tumor cells. Six previously reported patients with esophageal lymphoepithelioma-like carcinomas, and the current patient, all survived for longer than 24 months, a better outcome than that of patients with esophageal squamous cell carcinomas of usual type. The data suggest that this tumor arose as a mucosal, well-differentiated adenocarcinoma without lymphoid stroma and that EBV had no relation to either its pathogenesis or progression.
我们报告一例伴有淋巴样间质的食管巴雷特腺癌。我们认为这是该实体的首例报道病例，尽管此前已有6例食管淋巴上皮瘤样癌的报道。对一名58岁男性的食管肿瘤进行了组织学检查。还进行了原位杂交以检测爱泼斯坦-巴尔病毒（EBV）。肿瘤由浸润部分中具有密集淋巴细胞浸润的低分化腺癌和黏膜中无淋巴样间质的高分化腺癌组成。在癌旁观察到巴雷特上皮。肿瘤细胞中未检测到EBV阳性信号。先前报道的6例食管淋巴上皮瘤样癌患者以及本例患者均存活超过24个月，这一结果优于普通类型食管鳞状细胞癌患者。数据表明，该肿瘤起源于无淋巴样间质的黏膜高分化腺癌，且EBV与其发病机制或进展均无关。
