Simmons J W, Nordby E J, Hadjipavlou A G
Alamo Bone and Joint Clinic, San Antonio, Texas, USA.
Eur Spine J. 2001 Jun;10(3):192-202. doi: 10.1007/s005860000234.
This review presents the history of chemonucleolysis, the techniques, indications, contraindications, and complications. Presenting an historical overview and comparison of success rates with surgical discectomy may provide a fresh understanding of the controversy surrounding chemonucleolysis and establish its efficacy in relation to more invasive treatments. A review of the literature from 1973 through 1998 for chemonucleolysis, open discectomy, and microdiscectomy provided published success rates for these procedures, and a mean rate with standard deviation was determined. In the experience and opinion of the authors, chemonucleolysis remains a viable alternative for patients who have exhausted all conservative means of treatment. Proper patient selection leads to success rates comparable to open discectomy and microdiscectomy.
本综述介绍了化学髓核溶解术的历史、技术、适应证、禁忌证及并发症。呈现化学髓核溶解术的历史概述以及与手术椎间盘切除术成功率的比较，可能会为围绕化学髓核溶解术的争议提供新的理解，并确定其相对于更具侵入性治疗方法的疗效。对1973年至1998年关于化学髓核溶解术、开放性椎间盘切除术和显微椎间盘切除术的文献进行综述，得出了这些手术已发表的成功率，并确定了平均成功率及标准差。根据作者的经验和观点，对于用尽所有保守治疗方法的患者，化学髓核溶解术仍是一种可行的选择。正确选择患者可使成功率与开放性椎间盘切除术和显微椎间盘切除术相当。
