脊椎动物肢体发育过程中Slit和Robo家族成员的表达模式。
Expression patterns of Slit and Robo family members during vertebrate limb development.
作者信息
Vargesson N, Luria V, Messina I, Erskine L, Laufer E
机构信息
Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, 701 West 168th Street, New York, NY 10032, USA.
出版信息
Mech Dev. 2001 Aug;106(1-2):175-80. doi: 10.1016/s0925-4773(01)00430-0.
Abstract
We report the cloning and expression during limb development of the chicken Slit1, Slit2, and Slit3 ligands, and Robo1 and Robo2 receptor genes. We also compare the expression patterns of Robo1 and Robo2 in developing chick and mouse hindlimbs. These genes are expressed in regions of muscle development, chrondrogenesis, and axon guidance.
摘要
我们报告了鸡Slit1、Slit2和Slit3配体以及Robo1和Robo2受体基因在肢体发育过程中的克隆与表达情况。我们还比较了Robo1和Robo2在发育中的鸡和小鼠后肢中的表达模式。这些基因在肌肉发育、软骨形成和轴突导向区域表达。
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