Nogle L M, Okino T, Gerwick W H
College of Pharmacy, Oregon State University, Corvallis, Oregon 97331, USA.
J Nat Prod. 2001 Jul;64(7):983-5. doi: 10.1021/np010107f.
Bioassay-guided fractionation of organic extracts from two Lyngbya majuscula collections led to the isolation of a new secondary metabolite, antillatoxin B, an unusual N-methyl homophenylalanine analogue of the potent neurotoxin antillatoxin. Its structure was deduced from 2D NMR and data comparisons with antillatoxin. Antillatoxin B exhibited significant sodium channel-activating (EC(50) = 1.77 microM) and ichthyotoxic (LC(50) = 1 microM) properties.
对两个巨大鞘丝藻样本的有机提取物进行生物测定导向的分级分离，导致分离出一种新的次生代谢产物——安替拉毒素B，它是强效神经毒素安替拉毒素的一种不寻常的N-甲基高苯丙氨酸类似物。其结构通过二维核磁共振以及与安替拉毒素的数据比较推导得出。安替拉毒素B表现出显著的钠通道激活特性（半数有效浓度EC(50) = 1.77微摩尔）和鱼毒性（半数致死浓度LC(50) = 1微摩尔）。
