林格比毒素B，一种来自海洋蓝藻巨大鞘丝藻的有毒抗真菌次生代谢产物。
Lyngbyabellin B, a toxic and antifungal secondary metabolite from the marine cyanobacterium Lyngbya majuscula.
作者信息
Milligan K E, Marquez B L, Williamson R T, Gerwick W H
机构信息
College of Pharmacy, Oregon State University, Corvallis, Oregon 97331, USA.
出版信息
J Nat Prod. 2000 Oct;63(10):1440-3. doi: 10.1021/np000133y.
PMID:11076574
Abstract
Lyngbyabellin B (1) was isolated from a marine cyanobacterium, Lyngbya majuscula, collected near the Dry Tortugas National Park, Florida. This new cyclic depsipeptide displayed potent toxicity toward brine shrimp and the fungus Candida albicans. The planar structure was deduced using 1D and 2D NMR spectroscopic methods, and the stereochemistry is proposed through a combination of NMR and chiral GC/MS analysis.
摘要
林格比贝林B（1）是从佛罗里达州干龟岛国家公园附近采集的一种海洋蓝藻——巨大鞘丝藻中分离出来的。这种新的环缩肽对卤虫和白色念珠菌显示出强大的毒性。通过一维和二维核磁共振光谱方法推断出其平面结构，并结合核磁共振和手性气相色谱/质谱分析提出了其立体化学结构。
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