Herait P, Tursz T, Guillard M Y, Hanna K, Lipinski M, Micheau C, Sancho-Garnier H, Schwaab G, Cachin Y, Degos L
Tissue Antigens. 1983 Nov;22(5):335-41. doi: 10.1111/j.1399-0039.1983.tb02262.x.
Seventy-six North African patients (most from Algeria) affected with nasopharyngeal carcinoma (NPC) have been studied for their HLA-A, -B, and -DR phenotypes and compared with a control North African population. Antigens HLA-A3, HLA-B5 and HLA-Bw15 were found more frequently in the NPC group than in the control group (30.3% vs 17.6%, 38.2% vs 24.4% and 9.2% vs 0.8%, respectively). HLA-Aw33, HLA-B14 and HLA-DR4 were less frequent in the patients than in the controls (3.9% vs 16.8%, 1.3% vs 16% and 13.2% vs 29.1%, respectively). After correction for the number of specificities tested, these differences were not statistically significant. They were, however, more striking when compared to normal Kabyles (Algerian Berbers), a major ethnical population in Algeria, with lower incidences of the HLA-B5 antigen and of the HLA-Aw33-B14 haplotype. This could suggest, in North Africa, either the existence of MHC-linked genes of resistance or susceptibility to NPC, in Berbers especially, or a preferential occurrence of NPC in non-Berbers. Antibody titers against the Epstein-Barr virus (EBV) associated early antigen (EA) and viral capsid antigen (VCA) have been measured. No correlation was observed between HLA phenotypes and the anti-EBV serological response of the patients.
对76名患有鼻咽癌（NPC）的北非患者（大多数来自阿尔及利亚）进行了HLA - A、- B和 - DR表型研究，并与北非对照组人群进行了比较。发现NPC组中HLA - A3、HLA - B5和HLA - Bw15抗原的出现频率高于对照组（分别为30.3%对17.6%、38.2%对24.4%和9.2%对0.8%）。患者中HLA - Aw33、HLA - B14和HLA - DR4的出现频率低于对照组（分别为3.9%对16.8%、1.3%对16%和13.2%对29.1%）。在对所检测的特异性数量进行校正后，这些差异无统计学意义。然而，与正常卡比勒人（阿尔及利亚柏柏尔人）相比时，差异更为显著，卡比勒人是阿尔及利亚的主要民族群体，HLA - B5抗原和HLA - Aw33 - B14单倍型的发生率较低。这可能表明，在北非，尤其是在柏柏尔人中，存在与MHC相关的对NPC的抗性或易感性基因，或者NPC在非柏柏尔人中更易发生。已测量了针对爱泼斯坦 - 巴尔病毒（EBV）相关早期抗原（EA）和病毒衣壳抗原（VCA）的抗体滴度。未观察到HLA表型与患者抗EBV血清学反应之间的相关性。
