Harvey S C
Arch Int Pharmacodyn Ther. 1975 Feb;213(2):222-34.
In guinea pigs, 160 mug kg-1 of ouabain decreased noradrenaline content of the right atrium and left ventricle by 44% and 68%, respectively, 2 hr after intraperitoneal injection. In rats, 20 mg kg-1 decreased noradrenaline content of the right atrium and left ventricle by 35% and 55%, respectively, at 1 hr. In mice, 10 mg kg-1 decreased myocardial noradrenaline by 33% and 20 mg kg-1 by 45% at 15 min. Phenytoin, 10 mg kg-1 in the guinea pig, 80 mg-1 in the rat, and 40 mg kg-1, in the mouse suppressed the effect of ouabain. Hexamethonium did not suppress the effect. In isolated, perfused guinea pig and rat hearts, 5.5 + 10-8 M and 6.8 + 10-6 M, respectively, caused an increase in noradrenaline output, which was usually followed by oscillatory fluxes; the initial increase in output was obtunded and the oscillations were entirely prevented by premedication with phenytoin but not by the addition of the drug to the perfusion medium.
在豚鼠中，腹腔注射哇巴因160微克/千克后2小时，右心房和左心室的去甲肾上腺素含量分别降低了44%和68%。在大鼠中，20毫克/千克在1小时时使右心房和左心室的去甲肾上腺素含量分别降低了35%和55%。在小鼠中，10毫克/千克在15分钟时使心肌去甲肾上腺素降低了33%，20毫克/千克使其降低了45%。苯妥英，在豚鼠中为10毫克/千克，在大鼠中为80毫克/千克，在小鼠中为40毫克/千克，可抑制哇巴因的作用。六甲铵不能抑制该作用。在离体灌注的豚鼠和大鼠心脏中，分别为5.5×10⁻⁸摩尔/升和6.8×10⁻⁶摩尔/升时可使去甲肾上腺素释放增加，随后通常会出现振荡性通量变化；预先用苯妥英给药可抑制释放的初始增加并完全阻止振荡，但将药物加入灌注液中则无此作用。
