99mTc（V）二巯基丁二酸闪烁扫描术在肠道炎症检测与定位中的应用：与结肠镜检查及活检结果的比较

Use of 99mTc (V) DMSA scintigraphy in the detection and localization of intestinal inflammation: comparison of findings and colonoscopy and biopsy.

作者信息

Lee B F, Chiu N T, Wu D C, Tsai K B, Liu G C, Yu H S, Wang S T

机构信息

Department of Nuclear Medicine, National Cheng Kung University Hospital, 138 Sheng-Li Rd, Tainan 704, Taiwan.

出版信息

Radiology. 2001 Aug;220(2):381-5. doi: 10.1148/radiology.220.2.r01au30381.

DOI:10.1148/radiology.220.2.r01au30381

PMID:11477240

Abstract

PURPOSE

To evaluate the potential use of technetium 99m (99mTc) (V) dimercaptosuccinic acid (DMSA) scintigraphy in the detection and localization of intestinal inflammation.

MATERIALS AND METHODS

In a prospective study, 62 patients who were suspected of having intestinal inflammation and 30 control subjects were enrolled. All patients underwent 99mTc (V) DMSA scintigraphy and colonoscopy with biopsy within 1 week. 99mTc (V) DMSA scintigrams were interpreted blindly with respect to clinical information, and radiotracer uptake in the bowel segments was graded. The findings were then compared with the results of the colonoscopy and colonoscopic biopsy.

RESULTS

In the detection of intestinal inflammation, findings at 99mTc (V) DMSA scintigraphy were as follows: true-positive in 55, false-positive in two, true-negative in 32, and false-negative in three. Overall sensitivity was 95%; overall specificity, 94%; and overall accuracy, 95%.

CONCLUSION

Our results show that 99mTc (V) DMSA scintigraphy is a useful noninvasive diagnostic test for the detection and localization of intestinal inflammation.

摘要

目的

评估锝99m（99mTc）（V）二巯基丁二酸（DMSA）闪烁扫描术在检测和定位肠道炎症中的潜在应用。

材料与方法

在一项前瞻性研究中，纳入了62例疑似肠道炎症的患者和30例对照受试者。所有患者在1周内均接受了99mTc（V）DMSA闪烁扫描术及结肠镜检查并活检。99mTc（V）DMSA闪烁扫描图在不参考临床信息的情况下进行盲法解读，对肠段的放射性示踪剂摄取情况进行分级。然后将结果与结肠镜检查及结肠镜活检结果进行比较。