使用脂质乳剂中动脉注射超极化氙气对大鼠脑进行氙-129磁共振成像和波谱分析。
Xenon-129 MR imaging and spectroscopy of rat brain using arterial delivery of hyperpolarized xenon in a lipid emulsion.
作者信息
Duhamel G, Choquet P, Grillon E, Lamalle L, Leviel J L, Ziegler A, Constantinesco A
机构信息
Laboratoire mixte INSERM U438 / Université Joseph Fourier "RMN Bioclinique," Laboratoire de Recherche Correspondant du CEA, Grenoble, France.
出版信息
Magn Reson Med. 2001 Aug;46(2):208-12. doi: 10.1002/mrm.1180.
Hyperpolarized (129)Xe dissolved in a lipid emulsion constitutes an NMR tracer that can be injected into the blood stream, enabling blood-flow measurement and perfusion imaging. A small volume (0.15 ml) of this tracer was injected in 1.5 s in rat carotid and (129)Xe MR spectra and images were acquired at 2.35 T to evaluate the potential of this approach for cerebral studies. Xenon spectra consistently showed two resonances, at 194.5 ppm and 199.0 ppm relative to the gas peak. The signal-to-noise ratio (SNR) obtained for the two peaks was sufficient (ranging from 12 to 90) to follow their time courses. 2D transverse-projection xenon images were obtained with an in-plane resolution of 900 microm per pixel (SNR range 8-15). Histological analysis revealed no brain damage except in two rats that had received three injections.
溶解于脂质乳剂中的超极化（129）Xe构成一种核磁共振示踪剂，可注入血流中，用于测量血流量和进行灌注成像。将一小体积（0.15毫升）的这种示踪剂在1.5秒内注入大鼠颈动脉，并在2.35特斯拉的磁场强度下采集（129）Xe磁共振谱和图像，以评估这种方法用于脑部研究的潜力。氙谱始终显示出相对于气体峰在194.5 ppm和199.0 ppm处的两个共振峰。这两个峰获得的信噪比（SNR）足够高（范围为12至90），足以跟踪它们随时间的变化过程。获得了二维横向投影氙图像，其平面分辨率为每像素900微米（SNR范围为8至15）。组织学分析显示，除了两只接受了三次注射的大鼠外，没有发现脑损伤。
Zotero 插件