Kameyama K, Takami H, Miyajima K, Mimura T, Hosoda Y, Ito K, Ito K
Division of Diagnostic Pathology, Keio University Hospital, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.
Endocr Pathol. 2001 Spring;12(1):73-6. doi: 10.1385/ep:12:1:73.
Cowden's disease is an autosomal dominant disorder characterized by multiple benign and malignant neoplastic lesions involving many organs. The presence of characteristic cutaneous lesions is crucial for the diagnosis. Thyroid disease is a major extracutaneous manifestation of this disease; however, the histologic characteristics have not been described in detail. We report a case of thyroid tumor associated with Cowden's disease. Grossly, the tumor showed a multinodular appearance, like an adenomatous goiter. Microscopically, it consisted of follicular adenomas with a trabecular pattern. Some of the nodules had a second component resembling papillary carcinoma. This was thought to be a unique histological feature not described previously, and might be specific to thyroid tumor associated with Cowden's disease.
考登病是一种常染色体显性疾病，其特征为累及多个器官的多种良性和恶性肿瘤性病变。特征性皮肤病变的存在对诊断至关重要。甲状腺疾病是该疾病的主要皮肤外表现；然而，其组织学特征尚未得到详细描述。我们报告一例与考登病相关的甲状腺肿瘤病例。大体上，肿瘤呈多结节外观，类似腺瘤样甲状腺肿。显微镜下，它由具有小梁状结构的滤泡性腺瘤组成。一些结节有第二个成分，类似乳头状癌。这被认为是一种以前未描述过的独特组织学特征，可能是考登病相关甲状腺肿瘤所特有的。
