Michaels R D, Shakir K M
Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland.
J Endocrinol Invest. 1993 Dec;16(11):909-11. doi: 10.1007/BF03348956.
Cowden's Disease or multiple hamartoma syndrome is an autosomal dominant genodermatosis associated with abnormalities of the breast, thyroid gland, gastrointestinal tract and genitourinary system. A large percentage of these patients have goiters or other thyroid abnormalities. Physicians should consider the diagnosis of Cowden's disease in patients presenting with thyroid disease and skin lesions such as papules or skin tags and if present these subjects should be screened for other malignancies associated with this disease.
考登病或多发性错构瘤综合征是一种常染色体显性遗传性皮肤病，与乳腺、甲状腺、胃肠道和泌尿生殖系统的异常有关。这些患者中有很大比例患有甲状腺肿或其他甲状腺异常。医生在遇到患有甲状腺疾病且伴有丘疹或皮赘等皮肤病变的患者时，应考虑考登病的诊断，若存在此类情况，应对这些患者筛查与该疾病相关的其他恶性肿瘤。
