Yoshida K, Nakajima M, Niki Y, Matsushima T
Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School.
Nihon Kokyuki Gakkai Zasshi. 2001 Apr;39(4):260-5.
A 58-year-old woman with underlying rheumatoid arthritis was admitted to the hospital because of a dry cough and the presence of an abnormal shadow in the right lower lung field. Consolidation and volume loss in the right lower lobe with air bronchogram were recognized on a chest tomogram. Bronchofiberscopic examination disclosed neither stenosis nor tumors in the large bronchi. Organizing pneumonia was recognized pathologically in transbronchial lung biopsy (TBLB) specimens. The volume of the right lower lobe decreased rapidly, and new infiltration shadows appeared in the right upper and middle lobes. Another bronchofiberscope examination revealed organizing pneumonia, and macrophage infiltrations were seen in the alveoli on histopathological examination of the TBLB specimens. The diagnosis of RA-associated BOOP was made on the basis of agreement of the expansion of the shadows on chest radiographs, the RA symptoms and the RA factor. The patient was treated with prednisolone, and the clinical course was satisfactory, with no recurrence. This case was of interest because BOOP inducing lobar cicatricial atelectasis is very rare.
一名患有类风湿性关节炎的58岁女性因干咳及右下肺野出现异常阴影而入院。胸部断层扫描显示右下叶实变及体积缩小,并伴有空气支气管征。支气管纤维镜检查未发现大气道狭窄或肿瘤。经支气管肺活检(TBLB)标本的病理检查发现机化性肺炎。右下叶体积迅速减小,右上叶和中叶出现新的浸润阴影。再次支气管纤维镜检查显示机化性肺炎,TBLB标本的组织病理学检查发现肺泡内有巨噬细胞浸润。根据胸部X线片上阴影的扩大、类风湿性关节炎症状及类风湿因子,诊断为类风湿性关节炎相关的闭塞性细支气管炎伴机化性肺炎(BOOP)。患者接受泼尼松龙治疗,临床过程满意,无复发。该病例很有意思,因为BOOP导致大叶瘢痕性肺不张非常罕见。