某些5-取代溴吡唑啉螺巴比妥类药物的抗惊厥和镇静作用

Anticonvulsant and sedative effects of some 5-substituted bromopyrazolinic spirobarbiturates.

作者信息

Galati E M, Monforte M T, Miceli N, Raneri E

机构信息

Pharmaco-Biological Department, School of Pharmacy, University of Messina, Italy.

出版信息

Farmaco. 2001 May-Jul;56(5-7):459-61. doi: 10.1016/s0014-827x(01)01062-x.

DOI:10.1016/s0014-827x(01)01062-x

PMID:11482778

Abstract

We studied in mice the neuropharmacological effect of some 5-substituted bromopyrazolinic spirobarbiturates. LD50 and CL50 values were estimated for all the investigated compounds. The effect on potentiation of sodium pentobarbital activity and on generalised tonic-clonic seizures produced by PTZ on mice was studied. All the compounds had the same pharmacological profile, they extended sleeping-time induced by sodium pentobarbital and showed protection against PTZ-induced convulsions, decreasing the death rate.

摘要

我们在小鼠身上研究了一些5-取代溴吡唑啉螺巴比妥类药物的神经药理作用。对所有研究的化合物估计了半数致死量（LD50）和半数惊厥量（CL50）值。研究了这些化合物对戊巴比妥钠活性增强的影响以及对由戊四氮（PTZ）引起的小鼠全身性强直阵挛性惊厥的影响。所有化合物具有相同的药理特征，它们延长了戊巴比妥钠诱导的睡眠时间，并显示出对PTZ诱导惊厥的保护作用，降低了死亡率。