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新型双螺环氧化吲哚衍生物的一锅法三组分 1,3-偶极环加成反应的高效合成。

An efficient synthesis of novel dispirooxindole derivatives via one-pot three-component 1,3-dipolar cycloaddition reactions.

机构信息

Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China.

出版信息

Molecules. 2012 Oct 26;17(11):12704-17. doi: 10.3390/molecules171112704.

DOI:10.3390/molecules171112704
PMID:23103534
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6269013/
Abstract

A series of novel dispirooxindoles have been synthesized through three-component 1,3-dipolar cycloaddition of azomethine ylides generated in situ by the decarboxylative condensation of isatin and an α-amino acid with the dipolarophile 5-benzylidene-1,3-dimethylpyrimidine-2,4,6-trione. This method has the advantages of mild reaction conditions, high atom economy, excellent yields, and high regio- and stereo-selectivity.

摘要

通过靛红与α-氨基酸经脱羧缩合原位生成的亚胺叶立德与 5-亚苄基-1,3-二甲基嘧啶-2,4,6-三酮的 1,3-偶极环加成反应，合成了一系列新型的双螺环氧化吲哚。该方法具有反应条件温和、原子经济性高、产率高、区域和立体选择性好等优点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7547/6269013/25b01fde47e8/molecules-17-12704-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7547/6269013/2e15832fccf5/molecules-17-12704-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7547/6269013/4f4ff15ce3e1/molecules-17-12704-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7547/6269013/c052b366e717/molecules-17-12704-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7547/6269013/25b01fde47e8/molecules-17-12704-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7547/6269013/2e15832fccf5/molecules-17-12704-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7547/6269013/4f4ff15ce3e1/molecules-17-12704-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7547/6269013/c052b366e717/molecules-17-12704-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7547/6269013/25b01fde47e8/molecules-17-12704-g004.jpg

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