Gonzalvo Ibáñez F J, Fernández Tirado F J, Almárcegui Lafita C, Polo Llorens V, Sánchez Pérez A, Honrubia López F M
Hospital Universitario Miguel Servet, Zaragoza, España.
Arch Soc Esp Oftalmol. 2001 Aug;76(8):485-91.
To determine the ability of pattern-electroretinogram (PERG) to discriminate individual evolution of glaucomatous visual field losses in glaucoma suspects.
We studied 151 eyes of 78 GS, classified depending on their risk to develop glaucomatous damage. The initial visual field was normal. Those eyes showing at least 2 reduced amplitudes in the PERG components (P50, N95 and NP) were considered pathologic. The mean follow-up was 30 months (range: 13-50 months); the VF was evaluated at the end of the study.
At the beginning of the study the PERG was pathologic in 65 eyes (43%); in 45 of these eyes (69%) the visual field was pathologic at the end of the study. The positive predictive value of the PERG of visual field glaucomatous changes was 69% and the negative predictive value was 80%. The N95 amplitude showed the best predictive value, with 100% and 77% in the high and medium risk groups, respectively.
The PERG study can discriminate the glaucoma suspects that will develop visual field glaucomatous losses.
确定图形视网膜电图(PERG)鉴别青光眼可疑患者青光眼性视野损害个体进展情况的能力。
我们研究了78例青光眼可疑患者的151只眼,根据其发生青光眼性损害的风险进行分类。初始视野正常。那些PERG成分(P50、N95和NP)中至少有2个波幅降低的眼被视为病理性的。平均随访时间为30个月(范围:13 - 50个月);在研究结束时评估视野。
在研究开始时,65只眼(43%)的PERG为病理性;在这些眼中,45只眼(69%)在研究结束时视野为病理性。PERG对视野青光眼性改变的阳性预测值为69%,阴性预测值为80%。N95波幅显示出最佳预测值,在高风险组和中风险组中分别为100%和77%。
PERG研究能够鉴别出将会发生青光眼性视野损害的青光眼可疑患者。