Vitale C, Pellecchia M T, Grossi D, Fragassi N, Cuomo T, Di Maio L, Barone P
Department of Neurological Sciences, University Federico II, Naples, Italy.
Neurol Sci. 2001 Feb;22(1):105-6. doi: 10.1007/s100720170066.
We performed a clinical study to evaluate the unawareness of dyskinesias in patients affected by Parkinson's disease (PD) and Huntington's disease (HD). Thirteen PD patients with levodopa-induced dyskinesias and 9 HD patients were enrolled. Patients were asked to evaluate the presence of dyskinesias while performing specific motor tasks. The Abnormal Involuntary Movement Scale (AIMS) and Goetz dyskinesia rating scale were administered to determine the severity of dyskinesias. The Unified Parkinson's disease rating scale (UPDRS) and Unified Huntington's Disease Rating Scale (UHDRS) were used in PD and HD patients, respectively. In PD we found a significant negative relationship between unawareness score at standing and AIMS score and between unawareness score at hand pronation-supination and AIMS score for upper limbs. In HD we found a significant positive relationship between total unawareness score and UHDRS score and between total unawareness score and disease duration. In PD the unawareness seems to be inversely related with severity of dyskinesias, while in HD it is directly related to disease duration and severity.
我们开展了一项临床研究，以评估帕金森病（PD）和亨廷顿舞蹈病（HD）患者对异动症的 unaware。纳入了 13 例患有左旋多巴诱发异动症的 PD 患者和 9 例 HD 患者。要求患者在执行特定运动任务时评估异动症的存在情况。采用异常不自主运动量表（AIMS）和戈茨异动症评定量表来确定异动症的严重程度。分别对 PD 患者和 HD 患者使用统一帕金森病评定量表（UPDRS）和统一亨廷顿舞蹈病评定量表（UHDRS）。在 PD 患者中，我们发现站立时的 unaware 评分与 AIMS 评分之间以及上肢旋前 - 旋后时的 unaware 评分与 AIMS 评分之间存在显著负相关。在 HD 患者中，我们发现总体 unaware 评分与 UHDRS 评分之间以及总体 unaware 评分与病程之间存在显著正相关。在 PD 中，unaware 似乎与异动症的严重程度呈负相关，而在 HD 中，它与病程和严重程度呈正相关。
