Järvinen R, Knekt P, Hakulinen T, Rissanen H, Heliövaara M
Department of Clinical Nutrition, University of Kuopio, P.O. Box 1627, Kuopio, FIN-70211, Finland.
Br J Cancer. 2001 Aug 3;85(3):357-61. doi: 10.1054/bjoc.2001.1906.
The relationships between consumption of total fat, major dietary fatty acids, cholesterol, consumption of meat and eggs, and the incidence of colorectal cancers were studied in a cohort based on the Finnish Mobile Clinic Health Examination Survey. Baseline (1967-1972) information on habitual food consumption over the preceding year was collected from 9959 men and women free of diagnosed cancer. A total of 109 new colorectal cancer cases were ascertained late 1999. High cholesterol intake was associated with increased risk for colorectal cancers. The relative risk between the highest and lowest quartiles of dietary cholesterol was 3.26 (95% confidence interval 1.54-6.88) after adjusting for age, sex, body mass index, occupation, smoking, geographic region, energy intake and consumption of vegetables, fruits and cereals. Consumption of total fat and intake of saturated, monounsaturated, or polyunsaturated fatty acids were not significantly associated with colorectal cancer risk. Nonsignificant associations were found between consumption of meat and eggs and colorectal cancer risk. The results of the present study indicate that high cholesterol intake may increase colorectal cancer risk, but do not suggest the presence of significant effects of dietary fat intake on colorectal cancer incidence.
基于芬兰流动诊所健康检查调查的一个队列研究了总脂肪、主要膳食脂肪酸、胆固醇、肉类和蛋类的摄入量与结直肠癌发病率之间的关系。从9959名未被诊断出患有癌症的男性和女性中收集了前一年习惯性食物消费的基线信息（1967 - 1972年）。截至1999年末共确诊了109例新的结直肠癌病例。高胆固醇摄入量与结直肠癌风险增加相关。在调整了年龄、性别、体重指数、职业、吸烟、地理区域、能量摄入以及蔬菜、水果和谷物的消费量后，膳食胆固醇最高四分位数与最低四分位数之间的相对风险为3.26（95%置信区间1.54 - 6.88）。总脂肪的消费量以及饱和、单不饱和或多不饱和脂肪酸的摄入量与结直肠癌风险无显著关联。肉类和蛋类的消费量与结直肠癌风险之间未发现显著关联。本研究结果表明，高胆固醇摄入量可能会增加结直肠癌风险，但未表明膳食脂肪摄入量对结直肠癌发病率有显著影响。
