Zhang Renshuai, Zeng Jun, Liu Wenjing, Meng Jingsen, Wang Chao, Shi Lingyu, Yang Shanbo, Chang Jing, Xing Dongming
Qingdao Cancer Institute, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China.
School of Basic Medicine, Qingdao University, Qingdao, China.
Front Pharmacol. 2022 Aug 10;13:956619. doi: 10.3389/fphar.2022.956619. eCollection 2022.
Lipid metabolism appears to play significant roles in the development of cancer. Numerous studies have shown that the evolution of malignancies, including breast, prostate, and colorectal cancers, involves cholesterol in a profound manner. A crucial part in the intestinal absorption of cholesterol is played by Niemann-Pick C1-like 1 (NPC1L1), a cholesterol transporter protein that is widely expressed in the small intestine and liver. The importance of NPC1L1 in tumor prognosis has been demonstrated in investigations in the interim. NPC1L1 also has the potential to develop into a new therapeutic target and a cancer marker. There is, however, no comprehensive review that summarizes NPC1L1's function in cancer. To this end, we outlined NPC1L1's functions in carcinogenesis and treatment, along with resources that can be used to further comprehend the connection between NPC1L1 and tumors.
脂质代谢似乎在癌症发展中起着重要作用。大量研究表明，包括乳腺癌、前列腺癌和结直肠癌在内的恶性肿瘤的演变都与胆固醇密切相关。尼曼-匹克C1样1蛋白（NPC1L1）在肠道胆固醇吸收中起关键作用，它是一种在小肠和肝脏中广泛表达的胆固醇转运蛋白。在此期间的研究已经证明了NPC1L1在肿瘤预后中的重要性。NPC1L1还有潜力成为一种新的治疗靶点和癌症标志物。然而，目前尚无全面综述总结NPC1L1在癌症中的作用。为此，我们概述了NPC1L1在致癌作用和治疗中的功能，以及可用于进一步理解NPC1L1与肿瘤之间联系的资源。
