Das U N
EFA Sciences LLC, 1420 Providence Highway, Norwood, MA 02062, USA.
Prostaglandins Leukot Essent Fatty Acids. 2001 Jul;65(1):37-40. doi: 10.1054/plef.2001.0285.
Statins and polyunsaturated fatty acids have similar actions: both enhance endothelial nitric oxide synthesis, inhibit the production of pro-inflammatory cytokines, lower cholesterol levels, prevent atherosclerosis and are of benefit in coronary heart disease, stroke and osteoporosis. Statins enhance the conversion of linoleic acid and eicosapentaenoic acid to their long chain derivatives. Animals with essential fatty acid deficiency show an increase in HMG-CoA reductase activity, which reverts to normalcy following topical application of linoleic acid. Similarly to statins, polyunsaturated fatty acids also inhibit HMG-CoA reductase activity. In view of the similarity in their actions and as statins influence essential fatty acid metabolism, it is suggested that essential fatty acids and their metabolites may serve as second messengers of the actions of statins.
二者均能增强内皮一氧化氮的合成，抑制促炎细胞因子的产生，降低胆固醇水平，预防动脉粥样硬化，对冠心病、中风和骨质疏松症有益。他汀类药物可促进亚油酸和二十碳五烯酸向其长链衍生物的转化。患有必需脂肪酸缺乏症的动物，其HMG-CoA还原酶活性会增加，在局部应用亚油酸后可恢复正常。与他汀类药物类似，多不饱和脂肪酸也能抑制HMG-CoA还原酶活性。鉴于它们作用的相似性，且他汀类药物会影响必需脂肪酸代谢，因此有人提出必需脂肪酸及其代谢产物可能是他汀类药物作用的第二信使。
