Slavinsky J, Kissinger P, Burger L, Boley A, DiCarlo R P, Hagensee M E
Department of Microbiology, Immunology and Parasitology, Louisiana State Health Sciences Center, New Orleans, Louisiana 70112, USA.
Int J STD AIDS. 2001 Aug;12(8):516-23. doi: 10.1258/0956462011923615.
Human papillomaviruses (HPV) infecting the genital tract are associated with warts and anogenital malignancies. Although HPV is a highly prevalent sexually transmitted disease (STD), the majority of research has focused on female cohorts due to gender specific sequelae. Our objective was to measure the epidemiological features and seroprevalences of HPV-6/11 and 16 in a predominantly male group of STD clinic patients. High-risk individuals (n=687), who attended the public STD clinic were administered a behavioural questionnaire and serum tested for antibodies against HPV-6/11 and HPV-16 capsids via capture enzyme-linked immunosorbent assay. Despite the male predominance in this study, women were significantly more likely to have antibodies against both HPV-6/11 and HPV-16. Condom use appeared to be partially protective against HPV-16 seropositivity only. In conclusion, despite exhibiting increased risk behaviour, men were less likely to be HPV seropositive. Additional studies utilizing male cohorts are warranted to further elucidate this phenomenon.
感染生殖道的人乳头瘤病毒（HPV）与疣和肛门生殖器恶性肿瘤有关。尽管HPV是一种高度流行的性传播疾病（STD），但由于性别特异性后遗症，大多数研究都集中在女性群体上。我们的目标是测量以男性为主的STD门诊患者中HPV-6/11和16的流行病学特征和血清阳性率。对687名前往公共STD门诊的高危个体进行了行为问卷调查，并通过捕获酶联免疫吸附试验检测血清中针对HPV-6/11和HPV-16衣壳的抗体。尽管本研究中男性占主导地位，但女性更有可能同时拥有针对HPV-6/11和HPV-16的抗体。仅使用避孕套似乎对HPV-16血清阳性有部分保护作用。总之，尽管男性表现出更高的风险行为，但他们HPV血清阳性的可能性较小。有必要利用男性队列进行更多研究以进一步阐明这一现象。
