Armstrong F D
Department of Pediatrics, Dept. of Pediatrics (D-820), P.O. Box 016820, Miami, FL 33101, USA.
Front Biosci. 2001 Aug 1;6:G6-G12. doi: 10.2741/armstron.
Bone marrow transplantation offers a potential cure for a number of childhood cancers, sickle cell anemia, and stabilization of a deteriorating and debilitating process in a number of metabolic disorders and leukodystrophies. Depending upon the disease, treatment prior to BMT, and natural history of the disease, BMT may increase the risk of neuropsychological toxicity for children undergoing BMT, or may actually improve their long-term neurodevelopmental outlook. The role of factors such as pre-BMT therapy, age at time of treatment, presence or absence of total body irradiation, and toxicities associated with GVHD are presented for consideration. A developmental model for understanding the emergence of neurocognitive effects of BMT is reviewed, and strategies for intervention are considered.
骨髓移植为多种儿童癌症、镰状细胞贫血提供了潜在的治愈方法，还能稳定多种代谢紊乱和脑白质营养不良中不断恶化且使人衰弱的病程。根据疾病类型、骨髓移植前的治疗情况以及疾病的自然史，骨髓移植可能会增加接受移植儿童发生神经心理毒性的风险，也可能实际上改善他们的长期神经发育前景。文中介绍了诸如移植前治疗、治疗时的年龄、是否进行全身照射以及与移植物抗宿主病相关的毒性等因素的作用以供参考。回顾了一个用于理解骨髓移植神经认知效应产生的发育模型，并考虑了干预策略。
