Smedler A C, Bolme P
Department of Psychology, Stockholm University, Sweden.
Acta Paediatr. 1995 Apr;84(4):429-33. doi: 10.1111/j.1651-2227.1995.tb13665.x.
Bone marrow transplantation (BMT) involves conditioning with cyclophosphamide and, for patients with malignant disease, total body irradiation (TBI). This study describes the neuropsychological development of 10 children treated for leukemia (n = 7), neuroblastoma (n = 1) or severe aplastic anemia (SAA; n = 2) at 3 years of age or younger. A moderate general developmental delay, with pronounced motor deficits and varying degrees of perceptual and cognitive problems, was observed in all children treated for malignant disease. Children treated for SAA had normal development. We conclude that BMT, including TBI, can be directly associated with long-term neuropsychological impairment in children treated at a very young age. Continued medical and psychological follow-up procedures are needed.
骨髓移植（BMT）包括使用环磷酰胺进行预处理，对于患有恶性疾病的患者，还包括全身照射（TBI）。本研究描述了10名3岁及以下接受白血病（n = 7）、神经母细胞瘤（n = 1）或重型再生障碍性贫血（SAA；n = 2）治疗的儿童的神经心理发育情况。在所有接受恶性疾病治疗的儿童中均观察到中度的整体发育迟缓，伴有明显的运动缺陷以及不同程度的感知和认知问题。接受SAA治疗的儿童发育正常。我们得出结论，包括TBI在内的BMT可能与幼年接受治疗的儿童的长期神经心理损伤直接相关。需要持续进行医学和心理随访程序。
