Damian D L, Barnetson R S, Halliday G M
Department of Medicine (Dermatology), Melanoma and Skin Cancer Research Institute, University of Sydney at Royal Prince Alfred Hospital, Sydney, Australia.
Australas J Dermatol. 2001 Aug;42(3):161-7. doi: 10.1046/j.1440-0960.2001.00507.x.
Relatively few studies have examined the effects of low-dose ultraviolet (UV) radiation on in vivo human cutaneous immunity, or the ability of sunscreens to prevent UV-induced immunosuppression. We have studied the effects of solar-simulated UV radiation on nickel contact hypersensitivity (CHS) in nickel-allergic volunteers, and on delayed type hypersensitivity responses in Mantoux-positive volunteers. Nickel CHS and Mantoux responses were significantly suppressed by acute, suberythemal UV exposures equivalent to less than 8 min summer sunlight. Both UVA and UVB wavebands were immunosuppressive, but UVA-induced immunosuppression was transient, whereas UVB had a more sustained effect. Dose-responses for UV immunosuppression were determined using the nickel method, enabling calculation of in vivo sunscreen immune protection factors in a manner analogous with sun protection factor measurement. Sunscreens were found to confer significantly less protection against UV-induced immunosuppression than against UV-induced erythema.
相对较少的研究探讨了低剂量紫外线（UV）辐射对人体皮肤体内免疫的影响，或防晒霜预防紫外线诱导的免疫抑制的能力。我们研究了模拟太阳紫外线辐射对镍过敏志愿者的镍接触性超敏反应（CHS）以及对结核菌素试验阳性志愿者的迟发型超敏反应的影响。相当于夏季阳光照射不到8分钟的急性、亚红斑量紫外线照射显著抑制了镍CHS和结核菌素试验反应。UVA和UVB波段均具有免疫抑制作用，但UVA诱导的免疫抑制是短暂的，而UVB的作用更持久。使用镍法确定了紫外线免疫抑制的剂量反应，从而能够以类似于防晒系数测量的方式计算体内防晒霜的免疫保护系数。结果发现，防晒霜对紫外线诱导的免疫抑制的防护作用明显低于对紫外线诱导的红斑的防护作用。
