Kamijyo A, Matsuzaki Z, Kikushima K, Ogino J, Nozawa I, Matsuoka T, Endo S, Okamoto Y
Department of Otolaryngology, Yamanashi Medical University, 1110 Shimokato, Tamaho-cho, Nakakoma-gun, Yamanashi 409-3898, Japan.
Auris Nasus Larynx. 2001 Aug;28(3):227-32. doi: 10.1016/s0385-8146(01)00049-9.
effects of Fosfomycin (FOM) nebulizer therapy were studied in patients with chronic sinusitis.
about 28 patients with chronic sinusitis were administered 2 ml of FOM sodium (3% w/v) by nebulizer three times per week for 4 weeks. Levels of IL-1 beta, IL-6, IL-8, and TNF-alpha in nasal lavage were also measured before and at the end of treatment.
the overall efficacy of this treatment on the basis of both subjective and objective symptoms, was 'excellent' for 28.6%, 'good' for 10.7%, 'fair' for 39.4%, and yield 'no change' for 21.4% of the patients. Both IL-1 beta and IL-6 concentrations were significantly decreased after treatment. Although the IL-8 level did not significantly decrease, it seems to be related to the overall efficacy. TNF-alpha was not detected in all of the samples.
FOM nebulization therapy is highly effective in treatment for chronic sinusitis, and efficacy may be due to an immunomodulatory mechanism, as well as its bactericidal effect.
研究磷霉素（FOM）雾化治疗对慢性鼻窦炎患者的影响。
约28例慢性鼻窦炎患者通过雾化器每周3次给予2 ml磷霉素钠（3% w/v），共治疗4周。在治疗前和治疗结束时还测量了鼻腔灌洗中白细胞介素-1β（IL-1β）、白细胞介素-6（IL-6）、白细胞介素-8（IL-8）和肿瘤坏死因子-α（TNF-α）的水平。
基于主观和客观症状，该治疗的总体疗效为：28.6%的患者“优秀”，10.7%的患者“良好”，39.4%的患者“中等”，21.4%的患者“无变化”。治疗后IL-1β和IL-6浓度均显著降低。虽然IL-8水平没有显著降低，但似乎与总体疗效有关。所有样本中均未检测到TNF-α。
FOM雾化治疗对慢性鼻窦炎有高效，其疗效可能归因于免疫调节机制及其杀菌作用。
