McGrew R N, Wilson R S, Havener W H
Otolaryngology. 1978 Jan-Feb;86(1):ORL-147-51.
Several cases of sudden, irreversible blindness have been reported in the world literature following injections of various drug combinations in the head and neck. The common feature these drugs have is their capacity to either produce direct neurotoxic effects or embolic phenomena. Two new cases which resulted from injection of the combination of a depo or long-acting corticosteroid (methylprednisolone acetate, 40 mg) and a local anesthetic and epinephrine or penicillin were added to the growing world literature. The ocular and systemic pathologic findings are described and important questions are raised as to the pathophysiology. The need for an animal model experiment to answer as many of these questions as possible is emphasized.
世界文献报道了数例在头颈部注射各种药物组合后突然发生不可逆失明的病例。这些药物的共同特点是它们能够产生直接神经毒性作用或栓塞现象。又有两例新病例加入到不断增加的世界文献中，这两例是由于注射了长效皮质类固醇（醋酸甲泼尼龙，40毫克）与局部麻醉剂、肾上腺素或青霉素的组合所致。描述了眼部和全身的病理发现，并就病理生理学提出了重要问题。强调需要进行动物模型实验以尽可能多地回答这些问题。
