Wilson R S, McGrew R N, White H J
Ophthalmology. 1978 Sep;85(9):975-85. doi: 10.1016/s0161-6420(78)35593-7.
An experimental dog model was used to reproduce the clinical picture of bilateral arteriole and choriocapillaris occlusion from a unilateral intracarotid injection of long-acting corticosteroids combined with other drugs including lidocaine, epinephrine, and penicillin. All five known long-acting corticosteroids, when combined with 1:1000,000 epinephrine, elicited vasoconstriction followed by dilatation of the retinal vessels with particulate material occlusion of the retinal vessels and choriocapillaris associated with small retinal hemorrhages. The fluorescein picture is described. The particles were identified by polarization as the long-acting corticosteroid.
使用实验犬模型，通过单侧颈内动脉注射长效皮质类固醇与包括利多卡因、肾上腺素和青霉素在内的其他药物相结合，来重现双侧小动脉和脉络膜毛细血管阻塞的临床症状。所有五种已知的长效皮质类固醇与1:1000000肾上腺素联合使用时，均引发视网膜血管收缩，随后扩张，伴有视网膜血管和脉络膜毛细血管的颗粒物质阻塞，并伴有小的视网膜出血。描述了荧光素造影图像。通过偏振光鉴定这些颗粒为长效皮质类固醇。
