El-Thaher T S, Matalka K Z, Taha H A, Badwan A A
ARAGEN Biotechnology, Naor, Jordan.
Int J Impot Res. 2001 Aug;13(4):247-51. doi: 10.1038/sj.ijir.3900706.
Ferula harmonis, which is locally called 'zallouh' in the Middle East, is used as an aphrodisiac as it is reputed to enhance male sexual behavior, however, there is no scientific verification. In this study, the oil extracted from the seeds of Ferula harmonis was tested for its efficacy in enhancing erectile function and toxicity in male rats. The sexual activities assessed by penile erection index were dose dependent. The ED(50) (12.03 mg/kg) was 880 times less than the LD(50) (10.6 g/kg). However, when doses ranging from 0.05, 0.5 to 2 g/kg were given daily for 28 days, acute and subacute toxicity were observed. There was a decrease in total body weight, hepatomegaly, atrophic testis, significant decrease in hemoglobin and red blood cell count. In addition, there was a significant decrease in cholesterol level. All the above indicate that the crude oil from the plant Ferula harmonis can enhance erectile function, however, it becomes toxic if it is used for a long period of time. Further studies are underway to isolate and identify the active ingredients and their exact mechanisms of action.
中东地区当地称作“扎卢赫”的阿魏（Ferula harmonis），因其据称能增强男性性行为而被用作壮阳药，然而，尚无科学验证。在本研究中，对从阿魏种子中提取的油在增强雄性大鼠勃起功能方面的功效及其毒性进行了测试。通过阴茎勃起指数评估的性活动呈剂量依赖性。半数有效剂量（ED50）（12.03毫克/千克）比半数致死剂量（LD50）（10.6克/千克）低880倍。然而，当每天给予0.05、0.5至2克/千克的剂量，持续28天时，观察到了急性和亚急性毒性。出现了总体重下降、肝肿大、睾丸萎缩、血红蛋白和红细胞计数显著降低的情况。此外，胆固醇水平也显著下降。以上所有情况表明，阿魏植物的原油能增强勃起功能，然而，如果长期使用则会产生毒性。目前正在进行进一步研究，以分离和鉴定其活性成分及其确切作用机制。
