Fernandez de la Hoz K, Iñigo J, Fernandez-Martín J I, Arce A, Alonso-Sanz M, Gomez-Pintado P, Palenque E, Chaves F
Subdirección General de Sanidad Penitenciaria, Dirección General de Instituciones Penitenciarias, Madrid, Spain.
Int J Tuberc Lung Dis. 2001 Aug;5(8):696-702.
Culture-positive cases of tuberculosis (TB) from the urban population of southern Madrid and from all the prisons located throughout the city.
To determine the frequency with which common strains of Mycobacterium tuberculosis cause disease among patients from both the urban and prison populations of a large Spanish city.
Restriction fragment length polymorphism analysis was performed on culture-positive cases of TB identified between 1 January 1997 and 31 December 1998. Risk factors that might be associated with the dissemination of common strains of TB among the two populations were also investigated.
Two hundred and twenty-one cases of culture-positive TB were identified, 99 (47.8%) of which were grouped in 23 clusters. Eleven were general clusters that spanned the prison and urban populations involved 69 patients (31.2%). Univariate analysis of risk factors showed that age <35 years, human immunodeficiency virus (HIV) infection, intravenous drug use and current or previous imprisonment were all associated at a statistically significant level with inclusion in general clusters. The final logistic regression model showed an interaction between HIV infection and incarceration.
Dissemination of common strains of M. tuberculosis between prison inmates and the urban population of Madrid is significant, and involves subjects with a history of imprisonment and HIV infection.
来自马德里南部城市人口以及全市所有监狱中结核分枝杆菌培养呈阳性的结核病（TB）病例。
确定在西班牙一个大城市的城市和监狱人群中，常见结核分枝杆菌菌株导致疾病的频率。
对1997年1月1日至1998年12月31日期间确诊的结核分枝杆菌培养呈阳性的病例进行限制性片段长度多态性分析。还调查了可能与这两个人群中常见结核分枝杆菌菌株传播相关的危险因素。
共鉴定出221例结核分枝杆菌培养呈阳性的病例，其中99例（47.8%）被归为23个聚类。11个为一般聚类，跨越监狱和城市人群，涉及69名患者（31.2%）。危险因素的单因素分析表明，年龄<35岁、人类免疫缺陷病毒（HIV）感染、静脉吸毒以及当前或既往监禁在统计学上均与纳入一般聚类显著相关。最终的逻辑回归模型显示HIV感染与监禁之间存在交互作用。
马德里监狱囚犯与城市人群之间常见结核分枝杆菌菌株的传播较为显著，且涉及有监禁史和HIV感染的人群。
