招募恐惧症研究对象：有效性与成本
Recruiting phobic research subjects: effectiveness and cost.
作者信息
Kaakko T, Murtomaa H, Milgrom P, Getz T, Ramsay D S, Coldwell S E
机构信息
Department of Dental Public Health Sciences, University of Washington, Seattle, 98195-7475, USA.
出版信息
Anesth Prog. 2001 Winter;48(1):3-8.
Efficiently enrolling subjects is one of the most important and difficult aspects of a clinical trial. This prospective study evaluated strategies used in the recruitment of 144 dental injection phobics for a clinical trial evaluating the effectiveness of combining alprazolam with exposure therapy. Three types of recruitment strategies were evaluated: paid advertising, free publicity, and professional referral. Sixty-three percent of subjects were enrolled using paid advertising (the majority of them from bus advertisements [27.0%], posters on the University of Washington campus [20.1%], and newspaper advertisements [13.2%]). Free publicity (eg, television coverage, word of mouth) yielded 18.8% of enrolled subjects and professionaL referrals 14.6% of subjects. The average cost (1996 dollars) of enrolling 1 subject was $79. Bus and poster advertising attracted more initial contacts and yielded the greatest enrollment.
高效招募受试者是临床试验中最重要且最具挑战性的环节之一。这项前瞻性研究评估了在一项评估阿普唑仑与暴露疗法联合效果的临床试验中，用于招募144名牙科注射恐惧症患者的策略。评估了三种招募策略：付费广告、免费宣传和专业推荐。63%的受试者通过付费广告招募（其中大多数来自公交广告[27.0%]、华盛顿大学校园海报[20.1%]和报纸广告[13.2%]）。免费宣传（如电视报道、口碑传播）招募到18.8%的受试者，专业推荐招募到14.6%的受试者。招募1名受试者的平均成本（1996年美元）为79美元。公交和海报广告吸引了更多的初步接触者，并带来了最多的招募人数。
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