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颗粒入口分布对三分支肺气道模型中沉积的影响。

Effect of particle inlet distributions on deposition in a triple bifurcation lung airway model.

作者信息

Zhang Z, Kleinstreuer C

机构信息

Center for Environmental Medicine and Lung Biology, The University of North Carolina, Chapel Hill, USA.

出版信息

J Aerosol Med. 2001 Spring;14(1):13-29. doi: 10.1089/08942680152007864.

Abstract

Considering a triple bifurcation as a representative lung airway model of the upper bronchial tree, the effect of different random inlet particle distributions on deposition patterns and efficiencies have been numerically analyzed. The steady laminar three-dimensional transport equations for a dilute micron-size particle suspension have been solved using a commercial finite-volume code with user-enhanced programs. Particle release positions were assigned employing a random number generator following random-parabolic, random-uniform, and random-random distribution functions. Via back tracking, starting positions of all depositing particles were determined for each particle release distribution, including a deterministic-parabolic one which served as a base case. The results indicate that: (1) The starting regions of the depositing particles in a given bifurcation are fixed for the same inlet Reynolds number and Stokes number combination, regardless of the type of distribution profile. The situation for the particle deposition patterns is somewhat similar. However, the type of distribution of inlet particles strongly influences the particle deposition efficiencies. (2) Values of particle deposition efficiencies are very close for the same (parabolically) distributed deterministic versus random inlet particles when all other conditions are fixed. (3) According to the simulation validations, a determinstic parabolic distribution of inlet particles may be sufficient for laboratory data comparison purposes, but random distributions should reflect realistic environmental or medical aerosol inhalation more accurately.

摘要

将三重分支视为上支气管树的代表性肺气道模型,对不同随机入口颗粒分布对沉积模式和效率的影响进行了数值分析。使用带有用户增强程序的商业有限体积代码求解了稀微米级颗粒悬浮液的稳态层流三维输运方程。采用随机数生成器,根据随机抛物线、随机均匀和随机随机分布函数分配颗粒释放位置。通过反向追踪,针对每种颗粒释放分布确定所有沉积颗粒的起始位置,包括用作基准情况的确定性抛物线分布。结果表明:(1) 在给定的分支中,对于相同的入口雷诺数和斯托克斯数组合,沉积颗粒的起始区域是固定的,与分布轮廓的类型无关。颗粒沉积模式的情况有些相似。然而,入口颗粒的分布类型强烈影响颗粒沉积效率。(2) 当所有其他条件固定时,相同(抛物线)分布的确定性入口颗粒与随机入口颗粒的颗粒沉积效率值非常接近。(3) 根据模拟验证,入口颗粒的确定性抛物线分布可能足以用于实验室数据比较目的,但随机分布应更准确地反映实际环境或医学气溶胶吸入情况。

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