吸入前列腺素F2α、乙酰胆碱、组胺和柠檬酸后正常人呼吸道的支气管分泌物。
Bronchial secretion from normal human airways after inhalation of prostaglandin F2alpha, acetylcholine, histamine, and citric acid.
作者信息
Lopez-Vidriero M T, Das I, Smith A P, Picot R, Reid L
出版信息
Thorax. 1977 Dec;32(6):734-9. doi: 10.1136/thx.32.6.734.
Sputum produced by normal subjects after inhalation of prostaglandin F2alpha, acetylcholine, histamine, and citric acid has been analysed. Prostaglandin F2alpha was the most effective of the drugs in promoting sputum production. The material expectorated after inhalation of prostaglandin F2alpha shows the characteristics of mucoid sputum from patients with chronic bronchitis. The apparent viscosity and the concentration of marker substances for bronchial glycoprotein was in the lower part of the range found in mucoid chronic bronchitic sputum. The concentration of marker substances for serum glycoproteins and tissue fluid transudate were below the range found in chronic bronchitis, indicating that, in disease states, in addition to bronchial mucus there is a marked tissue fluid transudate component. Sputum produced after inhalation of acetylcholine and histamine contained relatively more tissue fluid transudate than sputum produced after inhalation of prostaglandin F2alpha, Sputum produced after inhalation of prostaglandin F2alpha, is of special value in indicating the nature of secretion from normal airways.
对正常受试者吸入前列腺素F2α、乙酰胆碱、组胺和柠檬酸后产生的痰液进行了分析。前列腺素F2α是促进痰液产生最有效的药物。吸入前列腺素F2α后咳出的物质显示出慢性支气管炎患者黏液样痰液的特征。支气管糖蛋白标志物物质的表观粘度和浓度处于黏液样慢性支气管炎痰液中发现范围的下限。血清糖蛋白和组织液渗出物标志物物质的浓度低于慢性支气管炎中发现的范围，表明在疾病状态下，除了支气管黏液外，还有明显的组织液渗出成分。吸入乙酰胆碱和组胺后产生的痰液比吸入前列腺素F2α后产生的痰液含有相对更多的组织液渗出物。吸入前列腺素F2α后产生的痰液在指示正常气道分泌物的性质方面具有特殊价值。
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