Liu C, Song R, Song Y
General Hospital of People's Liberation Army, Beijing 100853.
Zhonghua Zheng Xing Shao Shang Wai Ke Za Zhi. 1999 May;15(3):192-5.
This study investigated the possibility of a new approach, e.g. suture expansion osteogenesis for closing the posterior hard palate. By this technique we might hope to replace missing tissue in the clefts by tissue regeneration and achieve bony repair in the posterior hard palate and circumvent the problems of speech and facial growth seen in traditional cleft surgery.
Nine 8-month mongrel dogs were divided into three groups: the control(n = 1), sham control(n = 2) and the experimental group(n = 6). In six experimental dogs, an 8 mm wide cleft was made surgically. Suture expansion devices made of NiTi-shape memory alloy with force levels of 200 g, 360 g and 480 g were secured in the palatine bones to expand the lateral sutures of the palatine bones. Clinical and histological examinations were performed to observe the changes.
The clefts in the experimental group were closed completely sooner or later within a period from 5 to 14 days. While the clefts in the sham group became a little larger than their original size. There was significant new bone formation at the edge of the expanded suture.
The clefts in young dogs could be closed by the technique of suture expansion. The NiTi-SMA expander used in the study was consistently effective and all the force levels could induce a great amount of new bone formation with the trabeculae being thinner and longer by heavy forces.
本研究探讨一种新方法的可能性，即缝合扩张成骨术用于关闭硬腭后部。通过这种技术，我们有望通过组织再生替代腭裂缺损组织，实现硬腭后部的骨修复，并规避传统腭裂手术中出现的语音和面部生长问题。
将9只8个月大的杂种犬分为三组：对照组（n = 1）、假手术对照组（n = 2）和实验组（n = 6）。对6只实验犬进行手术制造一个8毫米宽的腭裂。将由镍钛形状记忆合金制成、力值分别为200克、360克和480克的缝合扩张装置固定在腭骨上，以扩张腭骨的侧缝。进行临床和组织学检查以观察变化。
实验组的腭裂在5至14天内迟早完全闭合。而假手术组的腭裂比其原始尺寸略有增大。在扩张缝边缘有明显的新骨形成。
幼犬的腭裂可通过缝合扩张技术闭合。本研究中使用的镍钛形状记忆合金扩张器始终有效，所有力值均可诱导大量新骨形成，且较大的力会使骨小梁更细更长。
