Ye Xin-ping, Peng Tao, Li Le-qun
Department of Hepatobiliary Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China.
Wei Sheng Yan Jiu. 2006 Nov;35(6):805-7.
Hepatocellualr carcinoma is one of the most malignancy, and the pathogenesis has not been clarified yet. The individual variation in the capacity of xenobiotic metabolizing and DNA repair was the genetic susceptibility to malignancies. Studies on polymorphisms of metabolic enzymes (CYP, NAT, GST, EH, ALDH) and DNA repair genes (XRCC1,hOGG1,XPD), and susceptibility to hepatocellular carcinoma are reviewed in this paper.
肝细胞癌是最具恶性的肿瘤之一，其发病机制尚未阐明。外源性物质代谢和DNA修复能力的个体差异是恶性肿瘤的遗传易感性。本文综述了代谢酶（CYP、NAT、GST、EH、ALDH）和DNA修复基因（XRCC1、hOGG1、XPD）的多态性与肝细胞癌易感性的研究。
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