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OR-1--a mixture of esters of glyceric acid produced by Penicillium funiculosum and its antitrypsin activity.

作者信息

Lesová K, Sturdíková M, Proksa B, Pigos M, Liptaj T

机构信息

Department of Biochemical Technology, Faculty of Chemical Technology, Slovak Technical University, 812 37 Bratislava, Slovakia.

出版信息

Folia Microbiol (Praha). 2001;46(1):21-3. doi: 10.1007/BF02825878.

DOI:10.1007/BF02825878
PMID:11501469
Abstract

A mixture of related metabolites (denoted OR-1) was isolated from the fermentation broth of Penicillium funiculosum together with mitorubrinic acid. Structurally OR-1 is glyceric acid esterified with C14-C18 fatty acids. Steady-state studies revealed that OR-1 behaved like an uncompetitive trypsin inhibitor with Ki 17.6 mumol/L.

摘要

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本文引用的文献

1
Production of (-)-mitorubrinic acid byPenicillium vermiculatum.青霉菌产生(-)-米托醌酸。
Folia Microbiol (Praha). 1997 Apr;42(2):133-5. doi: 10.1007/BF02898722.
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Chemopreventive agents: protease inhibitors.化学预防剂:蛋白酶抑制剂。
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微生物生产甘油酸,一种可以从甘油大量生产的有机酸。
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Funiculosin, a new antibiotic. I. Isolation, biological and chemical properties (studies on antiviral and antitumor antibiotics. 8).绳霉素,一种新型抗生素。I. 分离、生物学和化学性质(抗病毒和抗肿瘤抗生素研究。8)
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Antiinflammatory activity of the new mould metabolite 11-desacetoxy-wortmannin and of some of its derivatives.新型霉菌代谢产物11-去乙酰氧基渥曼青霉素及其某些衍生物的抗炎活性。
Experientia. 1974 Feb 15;30(2):135-6. doi: 10.1007/BF01927691.
6
SQ 30,957, a new antibiotic produced by Penicillium funiculosum. Taxonomy, fermentation, isolation, structure determination, synthesis and antibacterial activity.绳状青霉产生的新型抗生素SQ 30957。分类学、发酵、分离、结构测定、合成及抗菌活性。
J Antibiot (Tokyo). 1986 Aug;39(8):1054-8. doi: 10.7164/antibiotics.39.1054.
7
TAN-931, a novel nonsteroidal aromatase inhibitor produced by Penicillium funiculosum No. 8974. I. Taxonomy, fermentation, isolation,characterization and biological activities.TAN-931,一种由绳状青霉8974号菌株产生的新型非甾体芳香酶抑制剂。I. 分类学、发酵、分离、表征及生物活性
J Antibiot (Tokyo). 1991 Jun;44(6):589-99. doi: 10.7164/antibiotics.44.589.
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Increased activity and stability of poly(ethylene glycol)-modified trypsin.聚乙二醇修饰的胰蛋白酶活性和稳定性增强。
Enzyme Microb Technol. 1992 Feb;14(2):150-5. doi: 10.1016/0141-0229(92)90174-m.
9
Free fatty acids identified as antitryptic factor in soybeans fermented by Rhizopus oligosporus.在少孢根霉发酵的大豆中鉴定出的游离脂肪酸作为抗胰蛋白酶因子。
J Nutr. 1975 Oct;105(10):1351-5. doi: 10.1093/jn/105.10.1351.