Yu S, Beynen A C
Department of Nutrition, Faculty of Veterinary Medicine, Utrecht University, The Netherlands.
Biol Trace Elem Res. 2001 Jul;81(1):63-70. doi: 10.1385/BTER:81:1:63.
The effect of high arsenic intake on copper metabolism was investigated. Male rats aged 6 wk had free access to purified diets containing either 0 or 100 mg As/kg diet and demineralized water for a period of 2 wk. Arsenic was added to the diet in the form of NaAsO2. The high-arsenic diet decreased feed and water intake and body weight gain, but significantly increased liver weight. Kidney weight was not affected. Arsenic feeding drastically elevated kidney copper concentration, but significantly reduced copper concentration in plasma. Both true absorption and biliary excretion of copper were decreased significantly in rats fed the high-arsenic diet. True copper absorption was lowered essentially through the lower copper intake in the rats fed arsenic. It is speculated that arsenic feeding primarily leads to copper accumulation in the kidney, followed by a decrease in feed intake and thus in true, absolute copper absorption, a decrease in plasma copper concentration, and a decrease in biliary copper excretion.
研究了高砷摄入量对铜代谢的影响。6周龄雄性大鼠可自由摄取含0或100mg As/kg饲料的纯化日粮和去离子水，为期2周。以NaAsO₂的形式将砷添加到日粮中。高砷日粮降低了采食量、饮水量和体重增加，但显著增加了肝脏重量。肾脏重量未受影响。饲喂砷使肾脏铜浓度急剧升高，但显著降低了血浆铜浓度。高砷日粮喂养的大鼠铜的真吸收率和胆汁排泄量均显著降低。饲喂砷的大鼠真铜吸收率降低主要是由于铜摄入量降低。推测饲喂砷主要导致铜在肾脏中蓄积，随后采食量减少，从而真、绝对铜吸收减少，血浆铜浓度降低，胆汁铜排泄减少。
