Yu S, Beynen A C
Department of Human Nutrition, Wageningen Agricultural University, The Netherlands.
Br J Nutr. 1996 Dec;76(6):909-14. doi: 10.1079/bjn19960097.
The mechanism underlying the reduced Cu status in rats fed on a high-sulphide diet was investigated. Male rats aged 6 weeks were fed ad libitum on purified diets containing either 0 or 500 mg S2-/kg and demineralized water for a period of 2 weeks. The high-sulphide diet had no effect on feed intake, body-weight gain or weight of liver and kidney but significantly reduced Cu concentrations in plasma and kidney. Biliary Cu excretion was decreased significantly in rats fed on the high-sulphide diet. Apparent Cu absorption (Cu intake-faecal Cu) and true Cu absorption (Cu intake-(faecal Cu-biliary Cu)) were significantly lowered after sulphide feeding for 2 weeks. Rats fed on the high-sulphide diet excreted less Cu in urine than did the controls. We conclude that high sulphide intake reduces Cu status in rats through inhibition of Cu absorption which is reflected by a decrease in biliary Cu excretion as a secondary feature.
研究了以高硫饮食喂养的大鼠体内铜状态降低的潜在机制。6周龄雄性大鼠自由采食含0或500 mg S2-/kg的纯化日粮和软化水，持续2周。高硫饮食对采食量、体重增加或肝脏和肾脏重量没有影响，但显著降低了血浆和肾脏中的铜浓度。高硫饮食喂养的大鼠胆汁铜排泄显著减少。硫化物喂养2周后，表观铜吸收（铜摄入量-粪便铜）和真铜吸收（铜摄入量-（粪便铜-胆汁铜））显著降低。高硫饮食喂养的大鼠尿中铜排泄量低于对照组。我们得出结论，高硫摄入通过抑制铜吸收降低大鼠体内铜状态，这表现为胆汁铜排泄减少这一继发特征。
