Nie T, Abel T
Department of Biology, University of Pennsylvania, Philadelphia, 19104-6018, USA.
Behav Neurosci. 2001 Aug;115(4):951-6. doi: 10.1037//0735-7044.115.4.951.
Three mouse strains were examined for short- and long-term memory for Pavlovian fear conditioning measured 1 hr and 24 hr after conditioning. Both DBA/2J and CBA/J mice exhibit reduced long-term memory for contextual fear conditioning compared with C57BL/6J mice. In cued fear conditioning, however, DBA/2J mice show reduced short- and long-term memory compared with C57BL/6J mice, whereas CBA/J mice exhibit reductions only in short-term memory. These results underscore the importance of examining the time course of memory retention, and they suggest that inbred mouse strains may provide a diversity of phenotypes. The results also suggest that the processes of short- and long-term memory storage as well as contextual and cued fear conditioning are dissociable and are mediated by genetically distinct neurobiological mechanisms.
对三种小鼠品系进行了检查，以测试在条件反射后1小时和24小时测量的巴甫洛夫恐惧条件反射的短期和长期记忆。与C57BL/6J小鼠相比，DBA/2J和CBA/J小鼠在情境恐惧条件反射中的长期记忆均有所降低。然而，在线索性恐惧条件反射中，与C57BL/6J小鼠相比，DBA/2J小鼠的短期和长期记忆均有所降低，而CBA/J小鼠仅在短期记忆方面有所降低。这些结果强调了检查记忆保持时间进程的重要性，并且表明近交小鼠品系可能提供多种表型。结果还表明，短期和长期记忆存储过程以及情境和线索性恐惧条件反射是可分离的，并且由遗传上不同的神经生物学机制介导。
